Sildenafil Citrate of in Vitro Fertilization After Multiple IVF Failures Attributed to Poor Endometrial Development

Ain Shams University80 enrolled

Overview

The aim of this study is to evaluate the effect of sildenafil citrate on endometrial development in women with history of recurrent implantation failure after IVF

sildenafil citrate may increase endometrial thickness in women with recurrent IVF failure attributed to poor endometrial development

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

IVF Failure

Interventions

Sildenafil CitrateDRUG

25 mg orally, 4 times per day for 21 days

matching placeboDRUG

orally, 4 times per day for 21 days

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * (1) cases of infertility, older than 20 years of age and not older than 40 years. * (2) Body mass index (BMI):20-29. * (3) women have experienced two or more implantation failure attributed to inadequate endometrial development. Exclusion Criteria: * (1) Uterine abnormalities (e.g. septate, bicornuate and fibroid uterus, Asherman Syndrome). * (2) Any contraindication to sildenafil citrate or any of the components of its formulation including: * Concurrent use of organic nitrites and nitrates. * Severe hepatic impairment. * Severe renal impairment. * Hypotension. * Recent stroke or heart attack.

Locations (1)

Ain shams university

Cairo, Egypt

RECRUITING

Outcomes

Primary Outcomes

endometrial thickness measures

we will measure endometrial thickness by US in women with recurrent implantation failure

Time frame: 21 days

Central Contacts

ahmed khairy, professor

CONTACT

01090808047

Data from ClinicalTrials.gov

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