Remote Ischemic Conditioning Paired With Endovascular Treatment for Acute Ischemic Stroke

Inclusion Criteria: 1. Acute ischemic stroke where patient is ineligible for intravenous thrombolytic treatment or the treatment is contraindicated, or where patient has received intravenous thrombolytic therapy without recanalization; 2. Suspected proximal anterior circulation occlusion; 3. No remarkable pre-stroke functional disability (mRS ≤ 1); 4. Baseline NIHSS score obtained prior to randomization must be ≥6; 5. Age ≥18 and ≤ 80; 6. Patient treatable within 24 hours of symptom onset; 7. Informed consent obtained from patient or acceptable patient's surrogate Exclusion Criteria: 1. Identified hemorrhagic diathesis, coagulation factor deficiency, or oral anticoagulant therapy with INR \> 3.0; 2. Baseline platelet count \< 30\*109/L; 3. Baseline blood glucose of \< 2.7mmol/L or \>22.2mmol/L; 4. Renal insufficiency with creatinine ≥ 265 umol/L; 5. Severe, sustained hypertension (SBP \> 185 mmHg or DBP \> 110 mmHg); 6. Rapidly improving symptoms at the discretion of the investigator; 7. Seizures at stroke onset which would preclude obtaining a baseline NIHSS; 8. Serious, advanced, or terminal illness with anticipated life expectancy of less than one year; 9. History of life threatening allergy to contrast medium, Nickel, Titanium metals or their alloys; 10. Woman of childbearing potential who is known to be pregnant or lactating or who has a positive pregnancy test on admission; 11. Subject participating in a study involving other drug or device trial study; 12. Patients with a pre-existing neurological or psychiatric disease that would confound the neurological or functional evaluations; 13. Unlikely to be available for 90-day follow-up; 14. Contraindication for remote ischemic conditioning: severe soft tissue injury, fracture, or peripheral vascular disease in the upper limbs; 15. Hypodensity on CT or restricted diffusion amounting to an ASPECTS score of \<7 on noncontrast CT or \<6 on DWI MRI; 16. CT or MRI evidence of hemorrhage; 17. Significant mass effect with midline shift on CT or MRI scans; 18. Angiogram shows arterial tortuosity, pre-existing stent, and/or other arterial disease, which would prevent the device from reaching the target vessel and/or preclude safe recovery of the device; 19. Subjects with artery occlusions in multiple vascular territories; 20. Evidence of intracranial tumor.