"Double Low-Dose" DECT for HCC Imaging

Seoul National University Hospital68 enrolled

Overview

Hypothesis: double low-dose protocol provide better lesion conspicuity than standard protocol CT in patients at high-risk of HCC. patients who are scheduled for CECT for HCC diagnosis or surveillance are eligible for this study and allocated to either standard protocol or double-low dose protocol using spectral CT with low radiation dose and low dose of contrast media, within clinically accpetable range.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

TRIPLE

Enrollment

Conditions

HCC

Interventions

Double Low-Dose protocol CTDIAGNOSTIC_TEST

Double low-dose protocol CT (Low radiation dose quadriphasic liver CT and low dose of iodine contrast media) at spectral dual energy CT scanner

Standard protocol CTDIAGNOSTIC_TEST

standard protocol CT (standard dose quadriphasic liver CT and standard dose of iodine contrast media) at spectral dual energy CT scanner

Eligibility

Sex: ALLMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * high risk of HCC (chronic hepatitis B or C, or LC of any cause) * signed informed consent * scheduled for contrast enhanced liver CT for HCC surveillance or diagnosis Exclusion Criteria: * no risk factor for HCC * history of iodine hypersensitivity * renal dysfunction (Estimated GFR \< 30mL/min/1.73m2) or on dialysis * metformin medication within 48 hours * any other contraindication of CE-CT * BMI \> or = 30

Locations (1)

Seoul National University Hospital

Seoul, South Korea