To evaluate the influence of Salvianolate injection on myocardial microcirculation perfusion in subjects with STEMI who underwent primary PCI
This is a prospective, randomized, double-blind and controlled study.536 subjects of STEMI who underwent primary PCI within the first 12 hours will be enrolled.all patients were assigned to receive 300mg of asprin and ≥300mg of clopidogrel as loading dose,and following 100mg and 75mg once daily respectively.Patients were assigned to receive Salvianolate injection or 0.9% sodium chloride injection in catherter room setting,and following similar medicine once daily respectively for 7 days.Myocardial circulation perfusion will be checked with mmediate coronary angiography parameters,ECG,echocardiographic,CK-MB.The major adverse cardiovascular events will be observed.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
536
Patients will be assigned to receive 100ml of normal saline in catherter room setting,and following similar medicine once daily for 7 days.
Patients will be assigned to receive Salvianolate injection dissolved in 100ml of normal saline in catherter room setting,and following similar medicine once daily for 7 days.
Zhongshan Hospital Affiliated to Fudan University
Shanghai, Shanghai Municipality, China
RECRUITINGTIMI flow grade
Use TIMI flow grade to evaluate myocardial circulation perfusion
Time frame: an average of 2 hours
TIMI myocardial perfusion grade
Use TIMI myocardial perfusion grade to evaluate myocardial circulation perfusion
Time frame: an average of 2 hours
ST-segment resolution
Use ST-segment resolution to evaluate the epicardial blood flow perfusion
Time frame: up to 90 minutes
myocardial contrast echocardiograph
Use myocardial contrast echocardiograph to evaluate the myocardial microcirculation perfusion
Time frame: up to 7 days
creatine kinase isoenzyme
Use creatine kinase isoenzyme to evaluate myocardial infarct size
Time frame: up to 48 hours
major adverse cardiovascular events
all-caused death, re-infarction, target vessel revascularization, stroke
Time frame: an average of 30 days
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.