Kidney Disease and Pulmonary Hypertension

University of Giessen824 enrolled

Overview

Evaluation of the prevalence of kidney disease, hemodynamic predictors and long-term renal outcome in patients with invasively diagnosed pulmonary hypertension.

This study aims to determine the prevalence of kidney disease, hemodynamic predictors and long-term renal outcome of in-hospital patients with invasively diagnosed pulmonary hypertension at the Department of Pulmonology, University Hospital Giessen and Marburg, Giessen, Germany between 1999 and 2016.

Study Type

OBSERVATIONAL

Enrollment

824

Conditions

Pulmonary Hypertension

Interventions

No interventionOTHER

No intervention

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * older than 18 years * subjects with invasively diagnosed pulmonary hypertension at rest and available renal function and spot urine data at day of right heart catheterization between March 1999 and December 2016 at the Department of Pulmonology, University Hospital Giessen and Marburg, Giessen, Germany Exclusion Criteria: * subjects with estimated GFR \<15ml/min/1.73m2 or prior dialysis * pre-existing acute kidney injury * non-end stage renal disease with extracorporeal or peritoneal ultrafiltration due to diuretic-resistant fluid overload * primary kidney disease requiring active immunosuppression * autosomal dominant polycystic kidney disease * if subjects are pregnant * if subjects are recipients of solid-organ transplants * subjects with pulmonary hypertension with unclear/multifactorial mechanisms (WHO group 5 pulmonary hypertension)

Locations (1)

University Clinic Giessen and Marburg - Campus Giessen

Giessen, Hesse, Germany

Outcomes

Primary Outcomes

Changes in estimated glomerular filtration rate (GFR) in each class of pulmonary hypertension during follow-up period

Estimated GFR (Chronic Kidney Disease Epidemiology Collaboration) will be used over follow-up period to determine changes in renal function

Time frame: 3 years follow-up

Impact of renal function on deterioration of pulmonary hypertension during follow-up period

Changes in estimated GFR (Chronic Kidney Disease Epidemiology Collaboration) over follow-up period will be correlated with clinical worsening of pulmonary hypertension (as determined by echocardiography, 6-minute-walk, New York Heart Association classification, b-type natriuretic peptide)

Time frame: 3 years follow-up

Secondary Outcomes

Impact of pulmonary hypertension-related morbidity on renal function decline

Severity of pulmonary hypertension (progress pulmonary hypertension, unscheduled hospitalization due to worsening of pulmonary hypertension, mortality) will be correlated with changes in renal function (as determined by estimated GFR \[Chronic Kidney Disease Epidemiology Collaboration\])

Time frame: 3 years follow-up

Prevalence of proteinuria in pulmonary hypertension

24 hours urine collection at baseline will be assessed to predict progress of pulmonary hypertension

Time frame: At baseline

Impact of pulmonary hypertension-specific therapy on renal function decline

Estimated GFR (Chronic Kidney Disease Epidemiology Collaboration) over follow-up period will be assessed to show association of pulmonary hypertension-specific therapy on renal function

Time frame: 3 years follow-up

Data from ClinicalTrials.gov

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