Long-term PAS in Rehabilitation After SCI

Helsinki University Central Hospital5 enrolled

Overview

The investigators have recently shown in two pilot incomplete SCI patients that long-term paired associative stimulation is capable of restoring voluntary control over some paralyzed muscles and enhancing motor output in the weak muscles (1). In this study, the investigators will administer long-term paired associative stimulation to incomplete SCI patients in a long-term manner, keeping each patient in the study for as long as continuous improvement is observed.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Spinal Cord Injuries

Interventions

long-term paired associative stimulationDEVICE

Paired associative stimulation (PAS) administered 3 times per week. PAS comprises transcranial magnetic stimulation (eXimia magnetic stimulator, Nexstim Ltd, Helsinki, Finland) and peripheral nerve stimulation (given with Dantec Keypoint® electroneuromyography device (Natus Medical Incorporated, Pleasanton, CA, USA)).

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * incomplete SCI Exclusion Criteria: * epilepsy * metal inclusion in the head area * pacemaker * hearing device * high intracranial pressure

Locations (1)

BioMag laboratory, Helsinki University Central Hospital

Helsinki, Uusimaa, Finland

Outcomes

Primary Outcomes

Daniels and Worthingham's Muscle Testing

Time frame: 2 days after the last stimulation session

Daniels and Worthingham's Muscle Testing

Time frame: 1 month after the last stimulation session

Data from ClinicalTrials.gov

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