The purpose of the study is to evaluate the efficacy and safety of prophylactic use of antibiotics in endoscopic injection of tissue adhesive in gastric varices.
Gastroesophageal variceal bleeding is the most common and life-threatening condition in patients with portal hypertension, which are susceptibility to bacterial infection. However, the prophylaxis use of antibiotics remained uncertain and lack of high level evidences.This study is a randomized controlled trial. The purpose of the study is to evaluate the efficacy and safety of prophylactic use of antibiotics in endoscopic injection of tissue adhesive in gastric varices.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
912
Prophylactic use of antibiotics group：Prophylactic use of antibiotics during endoscopic treatment, cefotiam 2.0g intravenous
180 Fenglin Road
Shanghai, Shanghai Municipality, China
The incidence of infection after endoscopic treatment
Patients will receive body temperature, blood routine, inflammatory markers examination before and after endoscopic treatment
Time frame: 1 week
Rebleeding rate
Patients will be followed up and receive an endoscopic examination after patients have been followed up for 2 months.
Time frame: 2 months
Mortality rate
The investigators observe the mortality events during 2 months
Time frame: 2 months
All clinical events
All clinical events were defined as occurrence rebreeding, ascitic fluid infection, portal vein thrombosis, or death.
Time frame: 2 months
Serum endotoxin
Time frame: before and the first day after endoscopic treatment
inflammatory factors including IL-6, IL-8, TNF-a, IL-1beta，IL-2R, IL-10
Time frame: before and the first day after endoscopic treatment
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