Chronic low back pain patients aged 21 to 60 needed for a research study of the effects of transcranial direct current stimulation (tDCS) on the analgesic effects of lidocaine cream as measured by functional Magnetic Resonance Imaging (fMRI). Study will be conducted on nine separate days not requiring an overnight stay in the hospital.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
90
Electrical stimulation will be applied on the head to temporarily influence brain activity in specific regions.
Lidocaine cream will be applied to reduce pain sensitivity (analgesia).
A neutral cream will be applied as a control.
Martinos Center for Biomedical Imagin
Charlestown, Massachusetts, United States
RECRUITINGfMRI signal changes
Time frame: 2 days; Sessions 5 and 7
Gracely Scale pain rating changes
Time frame: 2 days; Sessions 2 and 7
resting state functional connectivity changes
Time frame: 2 days; Sessions 5 and 7
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.