Bone mineral density (BMD) is decreased after Roux-en-Y gastric bypass (RYGB) but whether RYGB induces changes in BMD beyond adaptation to major weight loss is not known. We aim to investigate BMD changes in weight bearing (hip, lumbal columna) and in non-weight bearing (forearm) regions before and after maximal weight loss at 1 year and after weight stabilisation at 4 years after RYGB. Moreover, plasma markers of bone turnover will be studied at fasting and during oral glucose tolerance test.
Study Type
OBSERVATIONAL
Enrollment
20
Roux-en-Y gastric bypass surgery for morbid obesity
Copenhagen University hospital Hvidovre
Copenhagen, Denmark
RECRUITINGChanges in bone mineral density of non-weight bearing bone
DXA scans of forearm
Time frame: 1 year, 4 years
Changes in bone mineral density of weightbearing bone
DXA scans of hip and lumbal columna
Time frame: 1 year, 4 years
Plasma markers of bone turnover
At fasting
Time frame: 1 week, 3 months, 1 year, 4 years
Plasma markers of bone turnover
during OGTT
Time frame: 3 months, 1 year, 4 years
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