After gastric sleeve patients undergo a substantial weight loss, but the physiological mechanisms behind the weight loss is not fully elucidated. Studies suggest that gut-hormone secretion is altered comparable to what is also seen after Roux-en-Y gastric bypass, however to which extent is not fully established and furthermore, the mechanisms behind an altered secretion are unclear. The purpose of this study is to investigate absorption and postprandial metabolism of glucose and protein in addition to gut hormonal responses after gastric sleeve compared with a group of un-operated subjects machted on sex, age and BMI. Furter, a group of Roux-en-Y gastric bypass operated patients matched on pre-operative BMI, current BMI, sex and age will be included for comparison.
Study Type
OBSERVATIONAL
Enrollment
36
Hvidovre University Hospital
Hvidovre, Please Select, Denmark
Glucose absorption
Between groups difference in peak Rate of appearance (Ra) of oral glucose tracer SG vs. CON
Time frame: 0 - 360 minutes
Protein absorption
Between groups difference in peak Ra of oral aminoacid tracer SG vs. CON
Time frame: 0 - 360 minutes
Glucose absorption
Between group difference in peak Ra of oral glucose comparing SG vs. RYGB
Time frame: 0 - 360 minutes
Protein absorption
Between groups differences in peak Ra of oral aminoacid tracer comparing SG vs. RYGB
Time frame: 0 - 360 minutes
Glucose kinetics
Between groups differences in AUC Ra of oral glucose tracer
Time frame: 0 - 360 minutes
Protein kinetics
Between groups differences in AUC Ra of oral aminoacid tracer
Time frame: 0 - 360 minutes
Insulin secretion
Between groups differences in iAUC of serum insulin and C-peptide
Time frame: 0 - 240 minutes
Glucagon-like Peptide 1 (GLP-1) secretion
Between groups differences in iAUC of plasma concentration of GLP-1
Time frame: 0 - 240 minutes
Glucose-dependent Insulinotropic Peptide (GIP)
Between groups differences in iAUC of plasma concentration of GIP
Time frame: 0 - 240 minutes
Ghrelin secretion
Between groups differences in iAUC of plasma concentration of ghrelin
Time frame: 0 - 240 minutes
Glucagon secretion
Between groups differences in iAUC of plasma cncentration of glucagon
Time frame: 0-240 minutes
Peptide YY
Between groups differences in iAUC of plasma concentration of PYY
Time frame: 0-240 minutes
Endogenous glucose production
Calculated via double tracer tecnique both in the fasting and post prandial state.
Time frame: -120 - 360 minutes
Lipolysis
Between groups differences in Rate of Disappearance of glycerol tracer.
Time frame: -120 - 360
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.