Short- and Long-Term Renal Outcomes Following Lung Transplantation

University of Giessen120 enrolled

Overview

Evaluation of acute kidney injury, renal recovery and development of chronic kidney disease in patients undergoing lung transplantation

It is well described that acute kidney injury and development of chronic kidney disease significantly impact short- and long-term survival after lung transplantation. However, there is limited data about prevalence of kidney disease according to current KDIGO consensus guidelines. It is the aim of this study to describe short- and long-term renal outcomes following lung transplantation. Selected patients who underwent prospective pretransplant renal functional reserve testing with high oral protein load will be analyzed separately in respect to occurrence of acute kidney injury following lung transplantation and development of chronic kidney disease.

Study Type

OBSERVATIONAL

Enrollment

120

Conditions

Lung Transplantation Acute Kidney Injury

Interventions

No interventionOTHER

No intervention

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

For retrospective analysis for all patients undergoing lung transplantation: Inclusion Criteria: * Older than 18 years Exclusion Criteria: * Patients with eGFR \<15ml/min/1.73m2 or with chronic dialysis treatment prior LTx * Patients undergoing retransplantation and multiorgan transplantation For prospective study involving patients with pretransplant renal functional reserve testing Exclusion criteria: * as above * unable to perform renal functional reserve testing (e.g., due to critical illness) * pre-existing acute kidney injury

Locations (1)

University Clinic Giessen and Marburg - Campus Giessen

Giessen, Hesse, Germany

Outcomes

Primary Outcomes

Impact of acute kidney injury (AKI) after lung transplantation on long-term renal function decline.

AKI defined by KDIGO consensus criteria

Time frame: 7 days

Secondary Outcomes

Impact of sustained reversal versus non-recovery after AKI on long-term renal function decline after lung transplantation.

AKI and CKD defined by KDIGO consensus criteria

Time frame: 3 years

Risk factors associated with development of AKI and CKD after lung transplantation

AKI and CKD defined by KDIGO consensus criteria

Time frame: 3 years

Whether development of CKD is an independent risk factor for increased rejection rate and death after lung transplantation.

CKD defined by KDIGO consensus criteria

Time frame: 3 years

Association between pretransplant renal functional reserve with acute kidney injury after after lung transplantation.

AKI defined by KDIGO consensus criteria

Time frame: 7 days

Association between pretransplant renal functional reserve and renal function loss after lung transplantation.

24h-creatinine clearance, estimated glomerular filtration rate

Time frame: 1 year

Data from ClinicalTrials.gov

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