An intraperitoneal implanted catheter is always necessary to perform Peritoneal Dialysis. Catheter insertion has been associated with infectious complication such as Exit Site Infection (ESI), Tunnel Infection and Peritonitis. The last one may lead to loss of the technique because the need of catheter removal. Most of international guidelines recommends the use of prophylactic antibiotics. Different protocols has been used, mostly intravenous single injection before the procedure. For the last 25 years our unit gives a single intraperitoneal dose of Cefazolin immediately after the catheter insertion. The aim of this study is compare the effect of a pre- operative IV dose os Cefazolin with a post- procedure intraperitoneal single dose administration of the same drug.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
200
A post- procedure administration of Cefazolin will be compared with a pre-operative intravenous dose
Carmel Medical Center
Haifa, Israel
RECRUITINGPeritonitis
Peritonitis asscociated catheter defined by cloudy effluent, high leukocyte count with neutrofilia
Time frame: 14 days
Exit site infection
Infection defined by purulent discharge or local redness
Time frame: 14 days
Tunnel infection
Inflammation in the subcutaneous tract of the peritoneal catheter
Time frame: 14 days
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