Increased plasma DPP4 activity (DPP4a) could predict both subclinical and new-onset atherosclerosis, and our previous study has found that the DPP4a was significantly lower in MI patients compared with patients having chest pain or unstable angina alone, and DPP4a is associated with no-reflow and major bleeding events in STEMI patients during hospital stay. As no-reflow phenomenon and major bleeding events independently associates with a worse in-hospital and long-term prognosis. One may speculate that the DPP4a is associated with long-term follow-up adverse cardiovascular events in these patients.The hypothesis was tested in this study.
Study Type
OBSERVATIONAL
Enrollment
625
DPP4a was determined by enzymatic assays.
major adverse cardiac or cerebrovascular events
including cardiovascular death, non-fatal myocardial infarction, heart failure and stroke
Time frame: The median follow-up was 30 months
non-cardiovascular death
Time frame: The median follow-up was 30 months
repeated revascularization
defined as repeated PCI or bypass grafting of not only infarct related artery but also non-infarct related artery, driven by ischemic symptoms (stable/unstable angina or re-infarction) or detection of ischemia by non-invasive tests
Time frame: The median follow-up was 30 months
stroke
defined using the World Health Organization criteria
Time frame: The median follow-up was 30 months
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