Brief Intervention for ICU Patients with Alcohol Use Disorders

University of Helsinki237 enrolled

Overview

Patients non-electively admitted to intensive care units (ICUs) will be screened for eligibility. The investigators will include adult patients with risk level alcohol use, defined by AUDIT-C score (\>5 for females, \>6 for males). Informed consent will be obtained from the patient in the end or shortly after the ICU treatment, when they have regained sufficient cognitive function. 600 patients will be randomized to receive either routine treatment or a brief intervention (BI). The BI includes a 20 minute discussion with pre-educated study personnel, option to discussion with a social worker and written material. Primary outcome measure is the amount of alcohol used during the preceding week (g/week), at 6 and 12 months after study entry. The information will be obtained 1)in an interview by a study team member blinded for the intervention arm at 6 months 2) A letter of a telephone interview at 12 months. AUDIT score, EQ-5D and mortality will also be recorded. An interim analysis by an external reviewer will be performed after the primary outcome has been recorded for 200 patients,

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

237

Conditions

Alcohol Use Disorder Critically Ill

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * AUDIT-C score \>5 (women) and \>6 (men) * Non-elective admission to the ICU Exclusion Criteria: * Terminal illness (expected to survive less than 6 months), palliative care * Diagnosed severe mental illness (psychos, severe depression, bipolar disorder, personality disorder) * Cognitive disability * Diagnosed dementia * Impaired level of consciousness at discharge from the ICU (expected to remain unchanged \>2 days * Other substance abuse (excluding cigarette smoking) * Ongoing treatment for alcohol dependency * Insufficient language skills (finnish/swedish) * Expected difficulty in getting contacted by mail or telephone (no permanent address or telephone in use)

Locations (3)

Helsinki University Hospital Intensive Care Units 20 and M1

Helsinki, Helsinki, Finland

Tampere University Hospital ICU

Tampere, Finland

Turku University Hospital

Turku, Finland

Outcomes

Primary Outcomes

Reported total amount of alcohol consumed during preceding week

The patients are interviewed and the amount of alcohol consumed during the last week is recorded and converted in grams

Time frame: 6 months after study enrollment

Reported total amount of alcohol consumed during preceding week

The patients are interviewed and the amount of alcohol consumed during the last week is recorded and converted in grams

Time frame: 12 months after study enrollment

Secondary Outcomes

Change in AUDIT score

The AUDIT score will be filled in an interview and compared with the initial score obtained on study admission

Time frame: 6 months after study enrollment

Change in AUDIT score

The AUDIT score will be filled in a telephone interview or by mailed questionnaire and compared with the initial score obtained on study admission

Time frame: 12 months after study enrollment

Mortality

Survival of the patients will be obtained from Statistics Finland

Time frame: One year after study enrollment

Quality of life

A structured questionnaire EQ-5D will be mailed or filled in a telephone interview and the EQ-5D will be compared between the groups