Effect of Preoperative Aspirin in Patients Undergoing Off-pump Coronary Artery Bypass Grafting

Medinet Heart Centre300 enrolled

Overview

Effect of Preoperative Aspirin in patients undergoing Off-pump Coronary Artery Bypass Grafting. A double-blind, placebo-controlled, randomized trial.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

300

Conditions

Coronary Artery Disease Aspirin

Interventions

AspirinDRUG

preoperative uncoated 75 mg Aspirin is administered 2 hours prior OPCAB

vitamin CDRUG

preoperative 75 mg Vit. C (Placebo) is administered 2 hours prior OPCAB

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Eligible patients undergoing off-pump coronary artery bypass grafting (OPCAB) * Patients in whom antiplatelet therapy was stopped 5-7 days prior to OPCAB Exclusion Criteria: * Patients undergoing on-pump coronary artery bypass grafting * Patients in whom antiplatelet therapy was not stopped 5-7 days prior to OPCAB * Intraoperative conversion to on-pump coronary artery bypass grafting * Patients with inherited blood-clotting disorders * Patients undergoing other cardiac operations

Locations (1)

Medinet Heart Centre

Nowa Sól, Lubusz Voivodeship, Poland

Outcomes

Primary Outcomes

Myocardial Injury

Myocardial injury detected by Troponin T (ng/ml)

Time frame: 6 hours following OPCAB

Myocardial Injury

Myocardial injury detected by Troponin T (ng/ml)

Time frame: 12 hours following OPCAB

Myocardial Injury

Myocardial injury detected by Troponin T (ng/ml)

Time frame: 24 hours following OPCAB

Myocardial Injury

Myocardial injury detected by Troponin T (ng/ml)

Time frame: 72 hours following OPCAB

Inflammation

Inflammation detected by CRP (mg/l)

Time frame: 6 hours following OPCAB

Inflammation

Inflammation detected by CRP (mg/l)

Time frame: 12 hours following OPCAB

Inflammation

Inflammation detected by CRP (mg/l)

Time frame: 24 hours following OPCAB

Inflammation

Inflammation detected by CRP (mg/l)

Time frame: 72 hours following OPCAB

Kidney Injury

Kidney injury detected by creatinine (mg/dl)

Time frame: 6 hours following OPCAB

Kidney Injury

Kidney injury detected by creatinine (mg/dl)

Data from ClinicalTrials.gov

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Effect of Preoperative Aspirin in Patients Undergoing Off-pump Coronary Artery Bypass Grafting

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes