Simultaneous Recordings of Cervical and Ocular Vestibular-evoked Myogenic Potentials

Chonbuk National University60 enrolled

Overview

To lower the threshold for clinical application by reducing the testing time for recording vestibular-evoked myogenic potentials (VEMPs), we evaluated whether a simultaneous recording of ocular and cervical VEMPs after unilateral or bilateral stimulation can be achieved without a loss in diagnostic sensitivity.

The combined evaluation of ocular and cervical VEMPs permits the assessment of both endorgans and whole vestibular nerve function, as well as the ascending and descending vestibular pathways in the brainstem at once. In about 30 healthy participants and 20 patients with acute unilateral vestibular neuritis, unilateral simultaneous cVEMP and oVEMP recordings in each side during monaural stimulation (air-conducted sound, 500Hz tone bursts, 100 nHL), and bilateral simultaneous recordings of each VEMP while binaural stimulation were compared to the conventional method of sequential recording each VEMPs on each side at a time.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Vestibular Function Disorder

Interventions

Vestibular evoked myogenic potentials (VEMPs)OTHER

The c- and oVEMPs will be assessed in three different sessions including conventional sequential recordings and two different simultaneous recording methods, i.e., unilateral simultaneous recording of cVEMPs and oVEMPs during monaural stimulation (Figure 1A) and bilateral simultaneous recording of each VEMP during binaural stimulation (Figure 1B).

Eligibility

Sex: ALLMin age: 15 YearsMax age: 85 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. acute onset of vertigo 2. the appearance of mixed horizontal and torsional nystagmus 3. impaired horizontal semicircular canal (SCC) function on head-impulse test and a unilaterally absent or reduced caloric response (i.e., a caloric paresis score \> 25%) 4. intact inferior division of vestibular nerve as evidenced by normal cVEMP and normal head-impulse test for vertical SCCs 5. the absence of auditory and neurologic signs Exclusion Criteria: * a previous history of vertigo or neuro-otologic diseases

Outcomes

Primary Outcomes

Clinical utility of simultaneous recordings of cervical and ocular vestibular-evoked myogenic potentials during monaural stimulation

The changes in the mean time for each recording

Time frame: 6 months

Secondary Outcomes

Clinical utility of simultaneous recordings of cervical and ocular vestibular-evoked myogenic potentials during monaural stimulation

VEMP parameters: latency

Time frame: 6 months

Clinical utility of simultaneous recordings of cervical and ocular vestibular-evoked myogenic potentials during monaural stimulation

VEMP parameters: peak-to-peak amplitude

Time frame: 6 months

Clinical utility of simultaneous recordings of cervical and ocular vestibular-evoked myogenic potentials during monaural stimulation

VEMP parameters: threshold

Time frame: 6 months

Data from ClinicalTrials.gov

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