Objectives: The aim of this study was to determine the effectiveness of preoperative administration of single-dose of paracetamol-codeine, in the relieving of acute post-operative pain after the surgical removal of an impacted mandibular third molar. Materials and Methods: The study cohort consisted of 32 Caucasian outpatients, giving a total of 64 bilateral symmetrical impacted mandibles. Patients were randomized in two experimental groups to receive a preoperative oral dose of paracetamol-codeine (analgesic group) or a placebo (placebo group) at the first and second surgeries. Study participants were asked to record pain intensity scores during the operation and the next 2 days, the time of the first request for rescue analgesic, and the total number of postoperative-supplement paracetamol-codeine tablets.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
32
preoperative administration
preoperative administration
Pain measurement assessed with the Numerical Rating Scale-11 (NRS-11) during the operative day.
The primary outcome of the study was the post-operative pain. Before surgery, patients were instructed to complete the Numerical Rating Scale-11 (NRS-11), which consisted of an interval scale ranging from 0 ("no pain") to 10 ("maximum pain")
Time frame: All study participants were asked to record the pain intensity score at 1:00 pm during the operative day
Pain measurement assessed with the Numerical Rating Scale-11 (NRS-11) during the operative day.
The primary outcome of the study was the post-operative pain. Before surgery, patients were instructed to complete the Numerical Rating Scale-11 (NRS-11), which consisted of an interval scale ranging from 0 ("no pain") to 10 ("maximum pain")
Time frame: All study participants were asked to record the pain intensity score at 6:00 pm during the operative day
Pain measurement assessed with the Numerical Rating Scale-11 (NRS-11) during the operative day.
The primary outcome of the study was the post-operative pain. Before surgery, patients were instructed to complete the Numerical Rating Scale-11 (NRS-11), which consisted of an interval scale ranging from 0 ("no pain") to 10 ("maximum pain")
Time frame: All study participants were asked to record the pain intensity score at 11:00 pm during the operative day
Pain measurement assessed with the Numerical Rating Scale-11 (NRS-11) during the 2th day after surgery.
The primary outcome of the study was the post-operative pain. Before surgery, patients were instructed to complete the Numerical Rating Scale-11 (NRS-11), which consisted of an interval scale ranging from 0 ("no pain") to 10 ("maximum pain")
Time frame: All study participants were asked to record the pain intensity score at 8:00 am during the 2th day after surgery
Pain measurement assessed with the Numerical Rating Scale-11 (NRS-11) during the 2th day after surgery.
The primary outcome of the study was the post-operative pain. Before surgery, patients were instructed to complete the Numerical Rating Scale-11 (NRS-11), which consisted of an interval scale ranging from 0 ("no pain") to 10 ("maximum pain")
Time frame: All study participants were asked to record the pain intensity score at 1:00 pm during the 2th day after surgery
Pain measurement assessed with the Numerical Rating Scale-11 (NRS-11) during the 2th day after surgery.
The primary outcome of the study was the post-operative pain. Before surgery, patients were instructed to complete the Numerical Rating Scale-11 (NRS-11), which consisted of an interval scale ranging from 0 ("no pain") to 10 ("maximum pain")
Time frame: All study participants were asked to record the pain intensity score at 6:00 pm during the 2th day after surgery
Pain measurement assessed with the Numerical Rating Scale-11 (NRS-11) during the 2th day after surgery.
The primary outcome of the study was the post-operative pain. Before surgery, patients were instructed to complete the Numerical Rating Scale-11 (NRS-11), which consisted of an interval scale ranging from 0 ("no pain") to 10 ("maximum pain")
Time frame: All study participants were asked to record the pain intensity score at 11:00 pm during the 2th day after surgery
Pain measurement assessed with the Numerical Rating Scale-11 (NRS-11) during the 3th day after surgery.
The primary outcome of the study was the post-operative pain. Before surgery, patients were instructed to complete the Numerical Rating Scale-11 (NRS-11), which consisted of an interval scale ranging from 0 ("no pain") to 10 ("maximum pain")
Time frame: All study participants were asked to record the pain intensity score at 8:00 am during the 3th day after surgery
Pain measurement assessed with the Numerical Rating Scale-11 (NRS-11) during the 3th day after surgery.
The primary outcome of the study was the post-operative pain. Before surgery, patients were instructed to complete the Numerical Rating Scale-11 (NRS-11), which consisted of an interval scale ranging from 0 ("no pain") to 10 ("maximum pain")
Time frame: All study participants were asked to record the pain intensity score at 1:00 pm during the 3th day after surgery
Pain measurement assessed with the Numerical Rating Scale-11 (NRS-11) during the 3th day after surgery.
The primary outcome of the study was the post-operative pain. Before surgery, patients were instructed to complete the Numerical Rating Scale-11 (NRS-11), which consisted of an interval scale ranging from 0 ("no pain") to 10 ("maximum pain")
Time frame: All study participants were asked to record the pain intensity score at 6:00 pm during the 3th day after surgery
Pain measurement assessed with the Numerical Rating Scale-11 (NRS-11) during the 3th day after surgery.
The primary outcome of the study was the post-operative pain. Before surgery, patients were instructed to complete the Numerical Rating Scale-11 (NRS-11), which consisted of an interval scale ranging from 0 ("no pain") to 10 ("maximum pain")
Time frame: All study participants were asked to record the pain intensity score at 11:00 pm during the 3th day after surgery
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