Assessment of myocardial ischemic-reperfusion injury during off- and on- pump CABG.
Assessment of myocardial ischemic-reperfusion injury during off- and on- pump CABG is monitored by intraoperative measurement of serum level of myeloperoxidase before sternotomy and after sternal closure.
Study Type
OBSERVATIONAL
Enrollment
336
Standard On-Pump CABG.
Standard Off-Pump CABG.
Patients with coronary artery bypass graft (CABG) surgery performed on beating heart with mechanical support of circulation
First Pavlov State Medical University of St. Petersburg
Saint Petersburg, Russia
Myeloperoxidase
Level of serum myeloperoxidase just after sternal closure
Time frame: Level of serum myeloperoxidase just after sternal closure
Low Cardiac Output Syndrome
Low cardiac output syndrome up to 30 days after procedure. Cardiac index (CI) was measured by invasive methods. Low cardiac output syndrome was registered when CI \<2.2.
Time frame: Up to 30 days after surgical procedure
Length of Stay in Intensive Care Unit
Length of stay in intensive care unit after operation.
Time frame: During 30 days after procedure or more
Length of Stay in Hospital
Length of stay in hospital
Time frame: During 30 days after procedure or more
Cumulative Dose of Inotrope
Calculated according: Cumulative dose of inotrope = Days dose of inotrope \* days of administration of inotrope
Time frame: Up to 30 days after procedure
Days of Administration of Inotrope
Period of inotrope administration
Time frame: During 30 days after procedure or more
Pulmonary Ventilation
Length of pulmonary ventilation
Time frame: During 30 days after procedure or more
Systolic Function
Measured with echocardiography (Ejection Fraction)
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Time frame: Up to 14 days after surgical procedure
Diastolic Function
Measured with echocardiography (End-Diastolic Volume)
Time frame: Up to 14 days after surgical procedure
Number of Participants With Reoperation
Number of participants with reoperation due to cardiac complication. Cardiac complication: graft dysfunction with cardiac index\<2.2.
Time frame: Up to 30 days after procedure
Renal Dysfunction
Serum creatinine level after surgical operation larger than 25% level before operation
Time frame: Perioperative (before sternotomy and after sternal closure)
Atrial Fibrillation.
New onset atrial fibrillation after operation.
Time frame: Up to 30 days after procedure