BIOLUX P-III SPAIN All-Comers Registry

Inclusion Criteria: * Age ≥ 18 years or minimum age as required by local regulations * Subject must be willing to sign a Patient Data Release Form (PDRF) or Patient Informed Consent (PIC) where applicable * Subject classified as Rutherford class 4, 5 or 6 * TASC C or D lesion(s) in the femoropopliteal artery * Lesion length \> 15 cm suitable for endovascular treatment treated with or scheduled to be treated with the Passeo-18 Lux drug releasing balloon Exclusion Criteria: * Life expectancy ≤ 1 year * Subject is currently participating in another investigational drug or device study that has not reached its primary endpoint yet. * Subject is pregnant or planning to become pregnant during the course of the study. * Rutherford class \<4 * Failure to successfully cross the target lesion with a guide wire (successful crossing means tip of the guide wire distal to the target lesion in the absence of flow limiting dissections or perforations). * Intraprocedural decision not to proceed with the Passeo18 Lux DCB for any reason not related to the device (for instance blood flow limiting dissection after predilatation).