During major surgical procedures, intravascular volume is maintained with the administration of isotonic fluids such as Lactated Ringers (LR), Normal Saline (NS) or Normosol-R. All three of these fluids are in common clinical use for this purpose. As large volumes of NS may result in a dilutional acidosis and an increasing base deficit, it may cloud clinical decision making when resuscitative efforts are guided by acid-base status on routine arterial blood gas analysis. This is a prospective, randomized study to evaluate changes in acid-base and electrolyte (sodium, potassium, calcium) status with the use of various isotonic fluids for intraoperative resuscitation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
59
IV infusion of 0.9% NaCl throughout surgery.
IV infusion of lactated ringer throughout surgery.
IV infusion of Normosol throughout surgery.
Nationwide Children's Hospital
Columbus, Ohio, United States
Change in Base Deficit
Change in base deficit from 1st to 2nd blood gas to measure metabolic acidosis
Time frame: During surgery (typically 4-6 hrs in length)
Change in Sodium
Change in sodium electrolyte from 1st to 2nd blood gas
Time frame: During surgery (typically 4-6 hrs in length)
Change in Potassium
Change in potassium electrolyte from 1st to 2nd blood gas
Time frame: During surgery (typically 4-6 hrs in length)
Change in Ionized Calcium
Change in calcium electrolyte from 1st to 2nd blood gas
Time frame: During surgery (typically 4-6 hrs in length)
Change in pH
Change in pH from 1st to 2nd blood gas
Time frame: During surgery (typically 4-6 hrs in length)
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