Cerebral Oxygen Saturation and Cytochrome Oxidase REDOX State in Children With Epilepsy: A Pilot Study

Medical College of Wisconsin34 enrolled

Overview

The purpose of this pilot study is to describe the relationship of regional cerebral oximetry and cytoximetry, measured using near-infrared spectroscopy, with seizure activity in the periictal period in children with epilepsy.

Pediatric subjects with partial (focal) epilepsy seizure disorders will be studied using near-infrared spectroscopy for cytochrome c oxidase (CCO) redox state and blood oxygen saturation. Along with routine EEG monitoring, a set of light sensors, called optodes, attached to a net/cap/device that goes over the head will be put on. These optodes will send out very weak red light signals, which will pass through the scalp and bounce back to detectors on the netting. The changes in the light signals will be used to calculate the changes in the various forms of the enzyme CCO, as well as the amount of oxygen in the blood. We hope to use these measurements to study changes in blood flow and cellular energy usage in the brain during seizures, which might help us to understand epilepsy better in the future and design better treatments.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Epilepsies, Partial

Interventions

Near-infrared spectroscopyDEVICE

Measurement of CCO redox state and cerebral oxygenation during epileptic seizures.

Eligibility

Sex: ALLMin age: 7 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Pediatric epilepsy patients who can provide assent (lower limit age 7). 2. Diagnosis of partial (focal) epilepsy and/or frequent interictal spike activity on EEG. 3. Clinical EEG supporting diagnosis of partial(focal) epilepsy and/or frequent interictal spike activity Exclusion Criteria: 1. History of unrepaired or palliated congenital cyanotic heart disease 2. History of traumatic head injury or head wounds to the extent that precludes safe and consistent placement of NIRS-EEG probes. 3. Guardian does not give consent or patient is unable to consent/assent to participate in the study 4. Clinical care provider or investigator determines the patient is not appropriate candidate for the study 5. Lack of current seizure care plan in Children's Hospital medical record 6. Known sensitivity or allergy to EEG gel

Locations (1)

The Medical College of Wisconsin

Milwaukee, Wisconsin, United States

Outcomes

Primary Outcomes

Change in CCO redox state and oxygen saturation

Regional cerebral saturation of oxygen and/or cytochrome oxidase redox state will change prior, during, and after onset of seizure activity when compared to non-seizure side of brain.

Time frame: 1 week

Data from ClinicalTrials.gov

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