TCF7L2 Polymorphisms Influence on Glycemic Control in ICU Patients With Organ Failure

University Hospital, Lille994 enrolled

Overview

This study evaluates the link between genetic polymorphisms as r7903146, rs12255372 of TCF7L2 gene and the risk of developing hyperglycemia during Intensive care unit stay

Study Type

OBSERVATIONAL

Enrollment

994

Conditions

Genetic Predisposition to Disease Hyperglycemia Intensive Care Unit Syndrome Multiple Organ Failure

Interventions

genetic analysisGENETIC

blood and stools samplesBIOLOGICAL

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * admission in ICU\>48h * at least one organ dysfunction Exclusion Criteria: * age\< 18 years * pregnant women * admission less than 48h

Locations (5)

CHU Cote de Nâcre

Caen, France

Hôpital Roger Salengro, CHRU de Lille

Lille, France

CH Victor Provot

Roubaix, France

CHU Charles Nicolle

Rouen, France

CH Tourcoing

Tourcoing, France

Outcomes

Primary Outcomes

value of the odds ratio associated with the relationship between a polymorphism TCF7L2 gene and the occurrence of hyperglycemia

find a link between genetic polymorphism of TCF7L2 and the risk of developing hyperglycemia in intensive care patients with a least one organ dysfunction. the hyperglycemia is defined fasting glucose\> 1.26 g / l twice or need for treatment with insulin)