The particpant will complete baseline testing by measuring subjects' quadriceps muscle thickness (cm) via ultrasound technology, as well as have them complete a one repetition maximum (1RM) test on the leg press machine and an isometric knee extension using a dynamometer - strength measures will be calculated for both right and left legs. After baseline testing, subjects will complete 6 weeks of the testing protocol that will consist of leg press exercises at 30% of their 1RM. Subjects will be randomized to either wear a cuff that partially restricts blood flow to the limb (Study Group), or to wear a cuff that does not restrict blood flow (Control Group). Exercises will be completed 2x/week and will take approximately 10 total minutes (5 for warm up, 5 for testing protocol) per session. After 6 weeks, muscle thickness, leg press 1RM, and quadriceps extension strength will be re-tested and compared to the initial measurements.
Session 1 - baseline testing * 5-minute warm-up; 1RM calculation for both right and left legs using a supine leg press machine; isometric quadriceps strength measurement using a dynamometer; muscle thickness measurements of both right and left quadriceps muscle using ultrasound technology. * After day 1 testing; randomly allocate subjects to either control group or experimental group Sessions 2-13 - 6 weeks of exercise protocol, 2x/per week Both the experimental and control groups will complete the same protocol for the entirety of the study: * 5- minute warm up * Using a single-leg press exercise machine: Subjects complete the testing protocol with either partial blood flow restriction (cuff inflated to 100-250 mmhg depending on size of person) or no blood flow restriction (placebo inflation) on right limb. * Protocol: 30 repetitions - 15 repetitions - 15 repetitions - 15 repetitions with each set separated by \~30-90 seconds. * Right and left legs will be alternating, but only one leg will have the occlusion cuff Session 14 - Re-test \- Re-check 1RM, isometric quad strength, as well as muscle thickness of quadriceps with ultrasound
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
8
The intervention is the wearing of a cuff-like band around the affected limb, of which partially restricts blood flow to the limb.
The intervention is the wearing of a cuff-like band around the affected limb, of which partially restricts blood flow to the limb.
Fairview Health Services
Minneapolis, Minnesota, United States
One Repetition Maximum
One repetition maximum on the single leg press. Isometric quadriceps extension strength.
Time frame: 6 weeks
Quadriceps Muscle Thickness
Difference between groups in the measurement of the muscle thickness of the quadriceps muscle via ultrasound.
Time frame: 6 weeks
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