First-in-Human Dose Escalation Study of M201-A in Healthy Japanese Subjects

Inclusion Criteria: Subjects must satisfy the following criteria to be enrolled in the study: * Japanese Healthy Male subjects * Age 20 to less than 40 years of age * Body Mass Index (BMI) of 18.5 to less than 25.0 kg/m2 * Written informed consent must be obtained on a voluntary basis before any assessment is performed. Exclusion Criteria: The presence of any of the following will exclude a subject from enrollment: * Presence or past medical history of hepatic impairments, renal impairments, cardiovascular disease, gastrointestinal disease and others which are inappropriate for participating in this clinical trial * Past medical history of cancer, cerebral infarction or cardiac infarction * Presence or past medical history of allergic reactions or idiosyncrasies to food, medicinal substance and metallic materials * QTcF \> 450ms at the screening examination * NT-proBNP \> 125 pg/mL at the screening examination * Any risk factors of Torsades de Pointes including such as heart failure, hypokalemia, long QT interval syndrome due to family medical history