The aim is to examine whether intranasal oxytocin will influence the individuals' emotion regulation ability and related neural mechanisms.
In the present study, the investigators plan to conduct a between-subject, double-blind, placebo-controlled experiment to investigate the effects of oxytocin on neural, physiological and behavior activity related to emotion regulation. The emotion regulation ability will be assessed by emotional go-nogo task and cognitive reappraisal task. The neural activity will be explored by functional magnetic resonance imaging (fMRI). And the investigators will record participants' heart rate during fMRI to investigate the effects of oxytocin on heart rate variability in emotion regulation process. All subjects completed a range of questionnaires measuring personality and affective traits and levels of anxiety before self-administration, including Positive and Negative Affect Schedule (PANAS) , State-Trait Anxiety Inventory (STAI) , Beck Depression Inventory (BDI), Cheek and Buss shyness Scale (CBSS), Autism Spectrum Quotient (ASQ), Empathy Quotient (EQ), Interpersonal Reactivity Index (IRI), Action Control Scale (ACS), Emotion Regulation Questionnaire (ERQ), Berkley Expressivity Questionnaire (BEQ), and so on.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
80
School of Life Science and Technology, University of Electronic Science and Technology
Chengdu, Sichuan, China
RECRUITINGOxytocin effects on neural activity during emotion regulation task
Neural activity will be measured by functional magnetic resonance imaging (fMRI). Differences in activity of prefrontal cortex (PFC) and amygdala will be compared between oxytocin and placebo groups during emotional go-nogo task and cognitive reappraisal task.
Time frame: Between 45-110 minutes after the intranasal administration of oxytocin
Oxytocin effects on heart rate variability during emotion regulation task
The heart rate will be recorded during the fMRI. The effects of oxytocin will be assessed by determining changes in heart rate variability between oxytocin and placebo groups during emotional go-nogo task and cognitive reappraisal task.
Time frame: Between 45-110 minutes after the intranasal administration of oxytocin
Oxytocin effects on behavior response during emotion regulation task
The effects of oxytocin will be assessed by determining changes in reaction time and accuracy during emotional go-nogo task and negative affect ratings during cognitive reappraisal task between oxytocin and placebo groups.
Time frame: Between 45-110 minutes after the intranasal administration of oxytocin
Oxytocin effects on heart rate variability during resting-state
The heart rate will be recorded during the resting-state. The effects of oxytocin will be assessed by determining changes in heart rate variability between oxytocin and placebo groups during resting-state.
Time frame: Between 35-45 minutes after the intranasal administration of oxytocin
Oxytocin effects on neural activity during resting-state
The effects of oxytocin will be assessed by determining changes in neural activity between oxytocin and placebo groups during resting-state.
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Time frame: Between 35-45 minutes after the intranasal administration of oxytocin