The SAMBA study aims to assess the safety and cost comparison of the management of outpatient alcohol detoxification, between an advanced nurse protocol on the one hand (experimental group), and a GP-based treatment on the other hand (standard-of-care group). In the advanced nurse (AN) group, nurses manage alcohol detox using a predefined protocol based on both the Cushman and CIWA-Ar scales. Depending on the Cushman and CIWA-Ar scores, which are calculated at every consultation, advanced nurse can adjust the diazepam dosing. In case of any serious adverse event or uncontrolled withdrawal complication, an addiction specialist stands in back-up and can be appealed to decide whether the outpatient detox can be continued or whether the patient has to be hospitalized. In the GP group, GPs can manage patients as they wish.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Enrollment
73
Protocoled AN-based management of detox
'As usual' medical management of detox
CH Beziers
Béziers, France
CH Boulogne
Boulogne, France
CHU Brest
Brest, France
CHU Clermont-Ferrand
Clermont-Ferrand, France
Csapa Anpaa63
Clermont-Ferrand, France
CHU Créteil
Créteil, France
CH Dunkerque
Dunkirk, France
CHU Grenoble
Grenoble, France
CH Lens - CSAPA Le Square
Lens, France
CSAPA CHRU - Le PARI
Lille, France
...and 16 more locations
Number of patients considered in failure of outpatient alcohol detoxification period
Hospitalization required (any cause) across the 15 days following the detox start
Time frame: 15 days
The total costs for each arm by cost-minimization
All medical costs (visits, medications, hospitalizations, ambulance,..) resulting from the detoxification management
Time frame: during the 15 days of the outpatient alcohol detoxification
Number of patients reporting at least one recovery in alcohol consumption
alcohol consumption obtained from A-TLFB data
Time frame: during the 15 days of the outpatient alcohol detoxification
Number of patients reporting at least one high alcohol intake
High alcohol intake defined by consumption of more than 5 standard drinks per day
Time frame: during the 15 days of the outpatient alcohol detoxification
Number of patients with adverse events
Time frame: during the 15 days of the outpatient alcohol detoxification
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