The Role of MSC in the Treatment of Fistulas in Patients With Perianal Crohn's Disease

Inclusion Criteria: 1. Age 18-65 years old, male or female; 2. refractory CD fistula, there are 1-2 and 1-3 in the mouth fistula; 3. Diagnostic CD at least three months; 4. CDAI \<250; 5. were receiving drug treatment (5-ASA and hormones\> 4 weeks, immunosuppressants and biological agents\> 8 weeks); 6. signed informed consent. Exclusion Criteria: 1. with intestinal obstruction, stenosis, or perianal abscess; 2. pregnant or lactating women; 3. infection needs antibiotics persons; 4. rectovaginal fistula; 5. complex anal fistula more than two inside the mouth; 6. stenosis or perforation CD; 7. perianal infection; 8. could not do rectal or anal stenosis local injection therapy; 9. with acute enteritis; 10. , liver and kidney dysfunction; 11. a month have used other drugs are in clinical trials; 12. no conditions or unwilling to carry out MRI inspected; 13. who are adjusting therapy; 14. HIV patients; 15. The combined active hepatitis or tuberculosis; Occurred in 16) 6 months opportunistic infections, or severe infections occur within three months; 17\) In the past five years, those who suffer from cancer; 18) there is a history of lymphoproliferative disease.