A Study on the Gastrointestinal Disease and Helicobacter Pylori Controlled Long Non-coding RNA

Yonsei University50 enrolled

Overview

Helicobacter pylori (H.pylori) is a major human pathogenic bacterium in gastric mucosa which is linked to the development of gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma and gastric cancer. However the regulatory mechanism of H.pylori-induced immune response is not clear. Long non-coding RNA (lncRNA) has recently emerged as key post-transcriptional regulators of gene expression, differentiation. The investigators had a preliminary results which THRIL (TNFα and hnRNPL related immunoregulatory lincRNA) and PACER(p50-associated COX-2 extragenic RNA) played a potential role in H.pylori induced inflammatory cascade. However, there wasn't a previous study about expression of THRIL, PACER in a human tissue. Therefore, the investigators aimed to evaluate the expression of THRIL, PACER in patients with gastrointestinal disease according to H.pylori infection.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Helicobacter Pylori Infection Gastric Ulcer Duodenal Ulcer Stomach Cancer

Eligibility

Sex: ALLMin age: 19 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Over 19 years old 2. Patients with gastric ulcer 3. Patients with duodenal ulcer 4. Patients with stomach cancer 5. Patients with gastrointestinal discomfort symptoms Exclusion Criteria: 1. Patients who has done helicobacter pylori eradication 2. Patients who has undergone gastrectomy 3. Patients who has undergone endoscopic submucosal dissection 4. Patients with active upper gastrointestinal bleeding

A Study on the Gastrointestinal Disease and Helicobacter Pylori Controlled Long Non-coding RNA

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Central Contacts