Open-label Study of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Auriхim

Inclusion Criteria: To participate in the clinical study, patients must comply to the following criteria: 1. Signed patient's information sheet and informed consent form 2. Males and females aged ≥ 18 years 3. The expected survival time not less than 6 months, with no need of an urgent intervention to eliminate life-threatening complications 4. Histologically and clinically confirmed at the screening diagnosis of В-cell, CD20-positive non-Hodgkin lymphoma of low tumor grade or follicular lymphoma, according to WHO's (World Health Organization) classification as of year 2008, namely: * Follicular lymphoma, cytological stage 1, 2 and 3a * Lymphoma from small lymphocytes (Small Lymphocytic Lymphoma) with number of peripheral blood lymphocytes \< 5,000/mсl * Lymphoplasmacytic lymphoma, including Waldenstrom's macroglobulinemia with paraprotein meaning (IgM ) \> 2,0 g/l * Extranodal marginal zone B-cell lymphoma of MALT-type * Nodal marginal zone B-cell lymphoma (± monocytoid В- lymphocytes) * Lymphoma of lien marginal zone cells. 5. Patients did not receive any therapy for the main disease, or disease recurrence, or refractivity after the previous therapy 6. II, III or IV disease stage according to Ann Arbor's classification and indications for immunotherapy, in the Investigator's opinion 7. The patient must have at least one 2-view measurable lesion (size by the long axis \> 1,5 cm and size by the short axis \> 1,0 cm, measured by means of CT scanner), that did not undergo radiotherapy in the past or appeared again in the course of the previous treatment. 8. Patients must have an ECOG status of 0 - 2 9. Requirements for laboratory parameters determined below: Hematology: Absolute neutrophil count: Platelets: Hemoglobin: ≥ 1500/mm3 (1.5 x 109 cells/L) * 100 000/mm3 (100 x 109 cells/L) * 8.0 g/dl Liver function: Total bilirubin: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT): ≤ 1.5 x ULN ≤ 2.5 x ULN Renal function: GFR (according to Cocroft-Golt formula): \> 30 ml/min. 10. The patients must be practicing effective methods of birth control during the whole period of the study and 12 months after the last administration of the investigational product. Exclusion Criteria: The patient will be considered ineligible for the study in case he/she has any criteria listed here below: 1. Chronic lymphocytic leukemia 2. CNS invasion now or in the history (lymphoma of CNS or lymphomatous meningitis) 3. Treatment by chemotherapeutic agents or radiotherapy within 4 weeks before screening, treatment by nitrosourea and mitomycin C within 6 weeks before screening or presence of ongoing toxicities of ≥ II grade according to CTCAE, related to the prior therapy (excluding alopecia) 4. Prior treatment by MAb (monoclonal antibodies) within 3 months before screening 5. Concomitant immunosupressive therapy and systemic treatment by corticosteroids on the moment of screening. 6. Clinically significant cardiovascular diseases: * Myocardial infarction within 6 months before screening * Unstable angina within 3 months before screening * Congestive heart failure Class III or IV according to the New York Heart Association (NYHA) criteria * Clinically significant ventricular arrhythmia (ventricular tachycardia, ventricular fibrillation) * QTc interval \> 460 ms (ECG) (calculated according to Fredericia formula), or a diagnosis of long QTc syndrome * Ejection fraction of left ventricle ≤ 50% (EchoCG) * Hypotension (systolic arterial blood pressure \< 86 mm of mercury) or bradycardia with a heart rate of \< 50 beats per min., except when caused by medications (e.g. beta-blockers) * Uncontrolled arterial hypertension (systolic arterial blood pressure \> 170 mm of mercury or diastolic arterial blood pressure \> 105 mm of mercury) 7. Peripheral neuropathy ≥ III severity level 8. Primary or secondary immunodeficiency now or in the history 9. Presence of antibodies to human immunodeficiency virus (HIV), or hepatitis С virus (HCV), active hepatitis B 10. Tuberculosis during last 5 years or positive result of the Quantiferon test 11. Active infection within 4 weeks before screening 12. Surgical interference (excluding biopsy of lymphatic nodes) within 4 weeks before screening 13. History of other malignancies with the exception of cervical carcinoma in situ or skin basal-cell carcinoma, that had undergone surgical removal and treatment within ≥ 5 years before screening 14. Uncontrolled concomitant diseases and conditions, including mental or social, which, in the Investigator's opinion, may prevent the patient from participation in the study. 15. Hypersensitivity to any of medicinal agents used in this study, to their compounds or to murine proteins, as well as significant, in the Investigator's opinion, allergic reactions in the history 16. Participation in other clinical studies or administration of other investigational products within 30 days before screening, or ongoing adverse reactions to any investigational product 17. Drug or alcohol abuse on the moment of screening or in the past, which, in the Investigator's opinion, makes the patient unsuitable for participation in the study. 18. Pregnant or lactating women, or women who plan to get pregnant during the clinical study; women of childbearing potential (not sterile and in postmenopause less than 2 years) who do not practice effective methods of birth control. Effective methods of birth control include usage of: * oral, injectable or transdermal contraceptives * a condom or diaphragm (barrier method) with spermicide, or * intrauterine device 19. Inability to read or write, unwillingness to understand and comply with the procedures of the study protocol, as well as any other concomitant medical or serious mental conditions, that make the patient unsuitable for participation in the clinical study, limit the validity of informed consent receipt or may affect the patient's ability to participate in the study -