Percutaneous microwave ablation(MWA) was reported as an effective modality for the management of thyroid nodules(TNs). This study aims to validate MWA as a feasible approach for patients with TNs for whom surgery is contraindicated or refused. Two groups of subjects with TNs(one group to treat with MWA and the other group to receive regular ultrasonic follow-up without any treatment) will be evaluated in term of TN volume, ultrasonic image and clinical symptoms.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
Ultrasound-guided Percutaneous Microwave Ablation
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, Zhejiang, China
RECRUITINGChange of the thyroid nodule volume assessed by ultrasonography after treatment vs simple clinical observation
Change of the thyroid nodule volume assessed by using ultrasonography, the volume reduction ratio(VRR) was calculated by the equation: VRR%=\[(initial volume-final volume)\*100\]/initial volume
Time frame: From time to treatment until 12 months. Time point evaluations at 1,3,6,12 months
Improved score on TN-related symptoms
Evaluation of TN-related neck symptoms scored separately as follow:0(absent),1(moderate),2(severe). The sum of the individual scores generates a final score(SYS score) ranging from 0 to 6
Time frame: From time to treatment until 12 months. Time point evaluations at 1,3,6,12 months
Improved cosmetic grading score
Cosmetic problem evaluated by grading score(1,no palpable mass;2, no cosmetic problem but palpable mass; 3, a cosmetic problem on swallowing only; and 4, a readily detected cosmetic problem
Time frame: From time to treatment until 12 months. Time point evaluations at 1,3,6,12 months
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