The BEST study will investigate the feasibility of cognitive interventions in a randomized, placebo-controlled, clinical trial. The investigators will recruit 45 cognitively normal subjects and engage them in one of three cohorts over an 8 week period, including active reading vs. origami study arms and a placebo group without structured cognitive intervention.
This is a randomized, placebo controlled study investigating the practical implementation and conduct of two cognitive interventions in non-demented subjects. Subjects will be randomized 1:1:1 into three groups including: 1) a Book club that includes weekly one hour meetings and daily reading assignments, 2) Origami lessons (one hour/week) with daily take home Origami activities to complete, and 3) a placebo group with unstructured lifestyle activities (normal lifestyle activities without restraint).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
45
The placebo group will have unstructured lifestyle activities (normal lifestyle activities without restraint).
Origami lessons (one hour/week) with daily take home Origami activities to complete
Book club that includes weekly one hour meetings and daily reading assignments
Sander's Brown Center on Aging
Lexington, Kentucky, United States
MOCA
The Montreal Cognitive Assessment (MOCA) measures general cognitive function
Time frame: 8 weeks
FCSRT
The Free and Cued Selective Reminding Test (FCSRT) measures memory function.
Time frame: 8 weeks
Adherence to protocol
Objective measures of weekly time devoted to cognitive training activities
Time frame: 8 weeks
Electroencephalogram
resting state electroencephalogram pattern
Time frame: 8 weeks
Evoked Related Potential
Evoked Related Potential P300 using the Bluegrass memory task
Time frame: 8 weeks
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