Human MesenchymAl Stem Cells Infusion in Patients With Cystic Fibrosis

Inclusion Criteria: * Provide written informed consent. * Be 20 - 45 years of age at the time of signing the Informed Consent Form. * Have a confirmed diagnosis of cystic fibrosis as defined by two or more clinical features of cystic fibrosis (CF), including by the 1997 CF Consensus criteria (NIH Consensus Statement, 1997): One or more accompanying clinical features consistent with Cystic fibrosis, and at least one of the following: 1. Documented sweat chloride test ≥ 60 mEq/L by quantitative pilocarpine iontophoresis or, 2. Abnormal nasal transepithelial potential difference (NPD) test or, 3. Two well-characterized, disease-causing genetic mutations in the CF transmembrane conductance regulator (CFTR) gene on different alleles * FEV1 at screening visit between 25% and 80% of predicted values for age, sex, and height taken 4 hours or more after last dose of short-acting bronchodilators (β-agonists and/or anticholinergics). The predicted values will be calculated according to National Health and Nutrition Examination Survey (NHANES). * Total bilirubin below 1.9 mg/dL. * Non-smoker for the past 60 days (2 months) prior to screening Visit 1 and less than a 5 pack-year lifetime history of smoking * Stable regimen of CF medications and chest physiotherapy for the 28 days prior to screening, and no anticipated need for changes during the study period for the immediate future, at least 4 weeks post infusion. * Clinically stable for at least 4 weeks with no evidence of new or acute respiratory symptoms, excluding symptoms of allergic (perennial or seasonal) or non-allergic rhinitis. * Patients should be on a stable medication regimen as determined by their Cystic fibrosis physician. Allowable medications include: * Inhaled medications (bronchodilators, steroids, pulmozyme, hypertonic saline and inhaled antibiotics to suppress chronic infections including tobramycin, amikacin, colistin, aztreonam lysine) * Chronic azithromycin use (three times weekly) * Vitamin supplementation * Pancreatic enzymes * CFTR potentiator and/or corrector (ivacaftor and lumacaftor) Exclusion Criteria: All subjects enrolled in this trial must not: * Be unable to perform any of the assessments required for endpoint analysis. * Use systemic corticosteroids (≥5 mg of prednisone per day). * Have been on intravenous or oral antibiotics within the last 4 weeks * Have a clinical history of malignancy within 5 years (i.e., subjects with prior malignancy must be disease free for 5 years), except curatively- treated basal cell carcinoma, squamous cell carcinoma, melanoma in situ or cervical carcinoma, if recurrence occurs. * Have congestive heart failure (NYHA Class III or IV). * Have severe pulmonary hypertension with a right ventricle systolic pressure (RVSP) \>50 mmHg as estimated by echocardiography * Have chronic kidney disease Stage 4 or 5. * Have a non-pulmonary condition that limits lifespan to ≤1 year. * Have clinically significant autoimmune disease (e.g., rheumatoid arthritis, systemic lupus erythematosus (SLE), or inflammatory bowel disease). * Have HIV, AIDS, or other immunodeficiency. * Test positive for hepatitis B HsAg, viremic hepatitis C, HIV1, HIV2, HTLV-I, HTLV-II, syphilis, and West Nile Virus. * Have a resting blood oxygen saturation of \<93% (measured by pulse oximetry). * Have documented current substance and/or alcohol abuse. * Be a current user of tobacco products. * Have a known hypersensitivity to dimethyl sulfoxide (DMSO). * Have had a recent (within prior 3 months) trauma or surgery. * Be an organ transplant recipient. * Be actively listed (or expected to be listed) for transplant of any organ other than for a lung transplant. * Have any clinically important abnormal screening laboratory values, including but not limited to: * hemoglobin \<12.1 g/dL (females) or \<13.6 g/dL (males). * white blood cell count \< 3000/mm3. * platelets \< 150,000/mm3. * International normalized ratio (INR) ˃ 1.5 not due to a reversible cause (i.e. Coumadin). * aspartate transaminase, alanine transaminase, or alkaline phosphatase ˃ 2 times upper limit of normal. * Have a sitting or resting systolic blood pressure \>180 mm Hg or diastolic blood pressure \>110 mm Hg at Screening. * Have any serious comorbid illness or any other condition that, in the opinion of the Investigator, may compromise the safety or compliance of the patient or preclude successful completion of the study, or that may compromise the validity of the study. * Be a female who is pregnant, nursing, or of childbearing potential while not practicing effective contraception (female patients must undergo a blood or urine pregnancy test at screening and prior to infusion). Females who are in childbearing age must agree to practice a highly effective form of contraception throughout the study. Highly effective forms of contraception with a low failure rate include barrier methods, oral contraception or depot contraceptives (unless on Orkambi), an intrauterine device, implantable devices. * Be currently participating in an investigational therapeutic or device trial, or have participated in an investigational therapeutic or device trial within the previous 30 days, or participate in any other clinical trial for the duration of the time that the subject actively participates in this trial.