Topically Applied IDP-118 Lotion and HP Monad Lotion in Subjects With Moderate to Severe Plaque Psoriasis

Inclusion Criteria: * Male or Female of any race, at least 18 years old of age (inclusive) * Freely provides both written and oral informed consent. * Has a clinical diagnosis of psoriasis at the Baseline visit with an Investigator's Global Assessment Score of 3 or 4. The face, scalp ,axillae, and intertriginous areas are to be excluded in this calculation. * Has an area of plaque psoriasis for topical treatment that involves a BSA of at least 20%. * The willing and able to avoid prolonged exposure of the treatment area to ultraviolet radiation (natural and artificial) for the duration of the study. Key Exclusion Criteria: * Has spontaneously improving or rapidly deteriorating plaque psoriasis or postural psoriasis, as determined by the investigator. * Presents with psoriasis that was treated with prescription medication and failed to respond to presents). * Has a history of adrenal disease. * Presents with any other concurrent skin conditions that could interfere with the evaluation of the treatment areas, as determined by the investigator. * Is pregnant, nursing, or planning pregnancy during the study period.