Evaluation of B+ Surface on Early Loading

Inclusion Criteria: * Patient \>18 and ≤75 years old * One missing tooth in the premolar or molar area with both opposing and adjacent teeth (mesial and distal). Exclusion Criteria: * One-stage bone augmentation * Heavy smokers (\>10 cigarettes/day) * Uncontrolled type 1 or 2 diabetes (HgA1c\>8) * Known auto-immune or inflammatory disease * Severe hematologic disorders, such as hemophilia or leukemia * Local or systemic infection that may compromise normal healing (e.g., extensive periapical pathology) * Liver or kidney dysfunction/failure * Currently receiving cancer treatment or within 18 months from completion of radio- or chemotherapy * Long-term history of oral bisphosphonates use (i.e., 10 years or more) * History of intravenous bisphosphonates * Long-term (\>3 months) history of antibiotics or drugs known to alter the inflammation and/or immunological system * Severe osseous diseases (e.g., Paget disease of bone) * Pregnant women or nursing mothers * Not able or not willing to follow instructions related to the study procedures