In this observational study, the investigators will examine the changes in body composition in HIV-infected subjects before and after initiation of HIV treatment, and look at the correlations with changes in cardiometabolic indices such as endothelial function and coronary calcium scoring.
The effects of lifestyle factors on body composition changes after antiretroviral therapy (ART) are unknown, and as such, investigators will use this prospective observational cohort to study relationships between lifestyle factors, including diet, physical activity and illicit drug use, with changes in body composition after ART. In addition, the effect of the body fat changes will be correlated to changes in cardiometabolic indices such as endothelial function and coronary calcium scoring.
Study Type
OBSERVATIONAL
Enrollment
56
University Hospitals Case Medical Center
Cleveland, Ohio, United States
Body composition measures
Assessed using DEXA (dual energy x-ray absorptiometry) scans which will be quantifying total body fat
Time frame: Baseline, 6-month, 1 year, 2 year, 3 year, 4 year, 5 year
Resting Energy Expenditure (REE) measures
Assessed using a BodyGem REE calculator (values in KCal)
Time frame: Baseline, 6-month, 1 year, 2 year, 3 year, 4 year, 5 year
endothelial function measures
Assessed using EndoPAT (values reported as a reactive hyperemia index RHI)
Time frame: Baseline, 6-month, 1 year, 2 year, 3 year, 4 year, 5 year
calcium score measures
Assessed using CT scans
Time frame: Baseline, 6-month, 1 year, 2 year, 3 year, 4 year, 5 year
central obesity
measured with waist circumference using a tape measure (in cm)
Time frame: Baseline, 6-month, 1 year, 2 year, 3 year, 4 year, 5 year
Lipids measures
used measuring blood levels of triglycerides (mg/dL); serum high-density lipoprotein (mg/dL) ; cholesterol (mg/dL); low density lipoprotein (mg/dL)
Time frame: Baseline, 6-month, 1 year, 2 year, 3 year, 4 year, 5 year
Fasting plasma glucose measures
fasting plasma glucose test is performed after a person has fasted for at least 8 hours (measured in mg/dL)
Time frame: Baseline, 6-month, 1 year, 2 year, 3 year, 4 year, 5 year
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Metabolic syndrome
Metabolic syndrome will be defined using the following measures: central obesity, serum triglycerides , serum high-density lipoprotein (HDL); cholesterol levels and fasting plasma glucose
Time frame: Baseline, 6-month, 1 year, 2 year, 3 year, 4 year, 5 year