Controlled hypotension has been used as a mean of reducing intraoperative blood loss and better visualization of the surgical field in nasal surgeries. Perfusion index has been considered a useful tool for monitoring changes in peripheral perfusion using Masimo set and serum lactate for central perfusion. Many medications were used to induce hypotension. In this study we will compare the effects of tridil and labetalol on the perfusion.
The purpose of this study to detect the degree of hypotension that helps the surgeon and dosen't impair patient's perfusion and to compare the hypotensive effects of both tridil and labetalol infusions on the perfusion.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Enrollment
40
Massimo is a newly introduced device which can measure the peripheral organ perfusion and expressed it as perfusion index(PI).
Nitroglycerin is a drug used as an hypotensive agent through its vasodilation effect on veins
Labetalol is an antagonist of adrenergic receptors (a1, b1, b2) which is used as an hypotensive inducer. This drug targets the beta receptors 5 to 10 times more specific than alpha receptors so that minor tachycardia happens
perfusion index
perfusion index is an indication of peripheral perfusion
Time frame: 3hrs
serum lactate level
lactate level is an indication of central perfusion
Time frame: 3hrs
surgical feild score
isan indication of adequacy of controlled hypotension
Time frame: 3hrs
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