The purpose of this study is to clarify whether the matching acupoints are more effective than a single point by electro-acupuncture in the management of chemotherapy-induced nausea and vomiting.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
208
Choose both Neiguan(PC6) and Zhongwan point(CV12).The needles are connected through a electro-acupuncture apparatus, the positive poles are linked to the needle, and the reference poles are located near the acupoint about 1cm with a electrode.Frequency is 2/10 hertz,the intensity of stimulation is adjusted according to the patient's tolerance, and the electric current is less than 10 milliampere. And plus 5-hydroxytryptamine-3 (5-HT3) antagonist (Ramosetron, Tropisetron,Granisetron or Ondansetron) and dexamethasone.
Choose Neiguan(PC6)of double upper limb.The needles are connected through a electro-acupuncture apparatus, the positive poles are linked to the needle, and the reference poles are located near the acupoint about 1cm with a electrode.Frequency is 2/10 hertz,the intensity of stimulation is adjusted according to the patient's tolerance, and the electric current is less than 10 milliampere. And plus 5-hydroxytryptamine-3 (5-HT3) antagonist (Ramosetron, Tropisetron,Granisetron or Ondansetron) and dexamethasone.
Tianjin University of TCM
Tianjin, Tianjin Municipality, China
RECRUITINGComplete Control rates of Nausea and Vomiting
There is no emetic episodes, no rescue therapy, and no significant nausea from first day of antiemetic therapy to 5th day.
Time frame: 6weeks
Complete Response rates of Vomiting
There is no emetic episodes and no rescue therapy on first day of antiemetic therapy and second day to 5th day.
Time frame: 6weeks
Nausea and Vomiting visual analogic scale (VAS)
Time frame: 6weeks
Tcm Gastro-intestinal evaluation
Time frame: 3weeks
the grading of constipation ,diarrhea and decrease in appetite
Number of participants with constipation ,diarrhea and decrease events as assessed by CTCAE v4.0
Time frame: 3weeks
Electrogastrogram
Time frame: 3weeks
Hospital Anxiety and Depression Scale
Time frame: 3weeks
Functional Assessment of Cancer Treatment - General scale4.0
Time frame: 3weeks
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