Shortly after the implementation of Comprehensive Chromosome Screening (CCS) techniques for Preimplantation Genetic Screening (PGS) came the transition in biopsy timing. Trophectoderm biopsy is meant to overcome the limitations of cleavage stage biopsy and single cell analysis.
The investigators have recently introduced this new approach and a frozen-thawed policy of euploid blastocysts is routinely performed. This is a single centre retrospective study in patients undergoing a PGS cycle. The aim of the study is to assess the results obtained in a PGS programme after the implementation of a new biopsy timing and transfer policy. Results obtained in PGS cycles with blastocyst biopsy and frozen-thawed embryo transfer were analysed in comparison to cycles with cleavage stage biopsy and fresh blastocyst transfer.
Study Type
OBSERVATIONAL
Enrollment
383
* intracytoplasmatic sperm injection (ICSI)- (Invitro Fertilization)IVF * Time lapse embryo culture * Cleavage stage biopsy * aCGH analysis * Fresh euploid embryo transfer
* ICSI-IVF * Time lapse embryo culture * Day 3 zona pellucida opening * Trophectoderm biopsy * aCGH analysis * Frozen-thawed euploid embryo transfer
Ongoing clinical pregnancy rate
Clinical pregnancy confirmed by ultrasound
Time frame: 20 weeks after embryo transfer
Implantation Rate
Embryos implanted confirmed by ultrasound
Time frame: 6 weeks after embryo transfer
Number of available euploid blastocysts per cycle
Transferable or vitrified euploid blastocysts
Time frame: Up to 15 days after embryo biopsy
Miscarriage Rate
Time frame: Until 20 weeks after embryo transfer
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