The study compares between the efficacy, safety and impact on the quality of life of radiofrequency thermocoagulation and chemical neurolysis of bilateral thoracic splanchnic nerves in the management of refractory pain which developed in patients suffering from upper abdominal cancer.
Radiofrequency thermocoagulation of splanchnic nerves was done bilaterally at level of thoracic vertebra T10 and T11 ( there were no enough studies done to test the efficacy, safety and impact on the quality of life of radiofrequency thermocoagulation of splanchnic nerves at level of T10 ). Aim of the Study is to compare between the efficacy, safety and impact on the quality of life of radiofrequency thermocoagulation of bilateral thoracic splanchnic nerves at level T10 and T11 vertebra and chemical neurolytic block of them at level of T11 vertebra only in the management of upper abdominal cancer pain.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
TRIPLE
Enrollment
79
sympathetic blockade or ablation of thoracic splanchnic nerves
sympathetic blockade or ablation of thoracic splanchnic nerves
sympathetic blockade or ablation of thoracic splanchnic nerves
South Egypt Cancer Institute
Asyut, Assuit Governrate, Egypt
RECRUITINGPain relief
Visual analogue pain scale
Time frame: 3 months
Decrease the need for analgesic drugs
Reduction of total oral morphine consumption dose in mg per day
Time frame: 3 months
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sympathetic blockade or ablation of thoracic splanchnic nerves