Shanghai Pediatric Cataract Study

Evidence Based Cataract Study Group10,000 enrolled

Overview

The purpose of this study is to evaluate the long-term visual outcome of the cataract surgery using a large-scale and comprehensive database of pediatric cataract participants, including congenital and traumatic cataract. The investigators will further investigate into the various genetic and environmental factors that may contribute to the pathogenesis of pediatric cataract.

Study Type

OBSERVATIONAL

Enrollment

10,000

Conditions

Pediatric Cataract Congenital Cataract Traumatic Cataract Visual Outcome Genetic Anticipation

Interventions

1）Pediatric cataract patients with intraocular lens implantation and those without intraocular lens implantation；2）Traumatic cataract patients with intraocular lens implantation and those without intraocular lens implantation

Eligibility

Sex: ALLMin age: 2 MonthsMax age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis of pediatric cataract * Must be able to cooperate with the ophthalmic examination Exclusion Criteria: * Clinical diagnosis of mental illness * Mentally disabled

Locations (1)

Eye and ENT Hospital of Fudan University

Shanghai, Shanghai Municipality, China

RECRUITING

Outcomes

Primary Outcomes

Differences in the visual outcomes of pediatric cataract patients.

Visual outcomes are evaluated including visual acuity with or without correction, refractive changes, intraocular pressure, fundus function, fixation type, vision development, growth of axial length, contrast sensitivity and other visual outcome measurements.

Time frame: Follow-up until ten years after surgery.

Genetic diversity based on biospecimen samples of pediatric cataract patients.

Sequencing of genes (including exons, promoters, 5' UTR and 3' UTR sequences) on a large scale to intensively investigate into the sites and functions of single nucleotide polymorphism (SNP) correlated with clinical features of congenital cataract patients, compared to traumatic cataract patients.Samples of blood, aqueous humor, anterior capsular membranes and lens tissues were applied for the genetic analysis.

Time frame: Analyzed within six months after surgery.

Secondary Outcomes

Differences in the clinical phenotypes of pediatric cataract patients.

Cataract type and severity of ametropic cataract patients are evaluated and images are captured before receiving the cataract surgery.

Time frame: Evaluated before receiving the cataract surgery.

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.