It is planned to evaluate if a porcine collagen matrix (Mucograft Seal) is offering comparable results to free gingival grafts (FGG) in post-extraction tissue preservation. If so, this would provide a substantial benefit to the patient as the second intervention on the palate and the subsequent morbidity of the donor site is omitted.
In a proof of concept 5 groups are compared in preserving soft- and hard tissue after tooth extraction in the esthetic zone: 1. Mucograft® Seal + Bio-Oss® 2. Free Gingival Graft (FGG) + Bio-Oss® 3. Free Gingival Graft + Gelatine sponge (Spongostan®) 4. Spongostan®+ Mucograft® Seal 5. Spongostan® Volumetric changes of hard and soft tissues are recorded , 2/4/8 weeks and 3/6/12 months after extraction.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
1
Placement of BioOss®-Collagen into the extraction socket. The Mucograft Seal® Membrane is then applied to the socket.
Placement of BioOss®-Collagen into the extraction socket. The FGG is then attached to the socket.
Placement of a Gelatine sponge into the extraction socket, then attaching the FGG to the socket.
Medical University Graz
Graz, Styria, Austria
Soft tissue volume
Time frame: 2 weeks
Soft tissue volume
Time frame: 4 weeks
Soft tissue volume
Time frame: 8 weeks
Bone volume
Time frame: 3 months
Bone volume
Time frame: 6 months
Bone volume
Time frame: 12 months
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Placement of a Gelatine sponge into the extraction socket, then attaching the Mucograft® Seal Membrane to the socket