Imaging the HIV Reservoir

Inclusion Criteria for All Groups: * Age 18 to 65 years * Able to give informed consent * A female, may be eligible to participate if she: * Is of non-child-bearing potential defined as either post-menopausal or incapable of becoming pregnant with documented tubal ligation, hysterectomy or bilateral oophorectomy or, * Is of child-bearing potential with a negative pregnancy test at screening and agrees to use one of the following methods of contraception consistently and for at least 8 weeks after receiving the investigational drug : * Complete abstinence from 2 weeks prior to investigational drug, and for at least 8 weeks after receiving the investigational drug * Double barrier method * Any intrauterine device (IUD) with published data showing that the expected failure rate is \<1% per year * Male partner sterilization confirmed prior to the female subject's entry into the study, and this male is the sole partner for that subject * Approved hormonal contraception * Any other method with published data showing that the expected failure rate is \<1% per year Group specific Inclusion criteria: Group 1 (HIV-uninfected) * A negative HIV Ag/Ab test at screening * Amenable to HIV risk reduction counselling and agrees to maintain behaviour consistent with low risk of HIV exposure Group 2 (HIV infected viremic off ART) * Documented HIV-1 infection * Not on ART for at least 8 weeks with HIV RNA plasma levels between 2,000 - 100,000 copies/ml * Current CD4+ T cell counts \>300 cells/μL * 3BNC117 sensitivity of subject derived HIV Group 3 (HIV infected aviremic on ART) * Documented HIV-1 infection * Receiving combination ART for at least 12 months * HIV-1 plasma RNA \<50 copies/mL for \> 12 months and \<20 copies/mL at screening. Episodes of a single HIV plasma RNA 50-500 copies/mL will not exclude participation if the subsequent HIV plasma RNA was \<50 copies/mL * Current CD4+ T cell counts \>300 cells/μL Exclusion Criteria for All Groups: * Any clinically significant acute or chronic medical condition that in the opinion of the investigator would preclude participation (e.g. lymphoproliferative disorders or significant resections of the gastrointestinal tract that would interfere with the distribution of HIV tissue reservoirs) * Receipt of a vaccination 14 days prior to receiving investigational drug * Previous use of histone deacetylase inhibitors or other latency reversing agents * Receipt of experimental HIV vaccine or monoclonal antibody therapy of any kind in the past * History of Hepatitis B (Positive HBsAg) or Hepatitis C co-infection (Individuals with prior hepatitis C infection that is now cleared are eligible for enrolment) * Subjects with severe hepatic impairment (Class C) as determined by Child-Pugh classification * Active alcohol or substance use that in the opinion of the investigator will prevent adequate compliance with study procedures * Currently pregnant, breastfeeding or unwilling to use barrier contraception * Women who are pregnant or breastfeeding or Women of Child Bearing Potential (WOCBP) who are unwilling or unable to use an acceptable method of contraception to avoid pregnancy as specified in the inclusion criteria * The following laboratory abnormalities: * Absolute neutrophil count ≤1,300 * Hemoglobin ≤ 10 gm/dL * Platelet count ≤125,000 * ALT ≥ 2.0 x ULN * Total bilirubin ≥ 1.5 ULN * Creatinine ≥ 1.1 x ULN