Tranexamic Acid (TXA) is an antifibrolytic medication used in total hip and knee arthroplasty to reduce the need for intraoperative and postoperative blood transfusions. Limited research is available on its use in hip fracture patients. We hypothesize that the use of TXA preoperatively, perioperatively, and postoperatively will decrease blood loss and need for blood transfusion postoperatively.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
200
Tranexamic acid is an antifibrinolytic used to control bleeding
Saline solution is used as the placebo comparator
ProMedica Toledo Hospital
Toledo, Ohio, United States
RECRUITINGproportion of patients requiring packed Red Blood Cell transfusion
units, perioperative
Time frame: 72 hours
intraoperative blood loss
mL
Time frame: 24 hours
postoperative anemia
Hgb \<7g/dL
Time frame: 72 hours
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