Postoperative Analgesia After Elective Hip Surgery - Effect of Obturator Nerve Blockade

University of Aarhus62 enrolled

Overview

The study investigates the effect of an obturator nerve block on the postoperative pain and opioid consumption after total hip replacement.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Obturator Nerve Block Total Hip Replacement

Interventions

Bupivacaine-epinephrineDRUG

Nerve block with 15 mL bupivacain 5 mg/mL with epinephrine 5 µg/mL.

Sham blockPROCEDURE

Injection as for obturator nerve block, but with placebo

Obturator nerve blockPROCEDURE

Postoperative obturator nerve block

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients for primary hip replacement in spinal anesthesia * Age \>= 18 years * American Society of Anesthesiologists physical status classification score I-III * Informed consent Exclusion Criteria: * Lacking the ability to corporate * Lacking the ability to speak danish * Planned discharge on the same day of surgery * Neuropathy of the lower extremities * Contraindications for NonSteroidal Anti-Inflammatory Drugs (NSAID) * Contraindications for dexamethasone * Chronic opioid demanding pain * Pregnancy * Allergy towards one or both investigatory medicinal products * Active treatment with amiodarone * Active treatment with verapamil * Active treatment with corticosteroids

Locations (1)

Elective Surgery Centre

Silkeborg, Denmark

Outcomes

Primary Outcomes

Opioid dose 0-12 hour after total hip replacement

Cumulated dose of opioid 0-12 hour after total hip replacement

Time frame: 0-12 hour after completion of total hip replacement

Secondary Outcomes

Cumulated dose of opioid 12-18 hours after total hip replacement.

Time frame: 12-18 hours after completion of total hip replacement

Pain at rest at time of examination (numeric rating scale)

Time frame: 1, 2, 5, 7 and 24 hours after completion of total hip replacement

Pain at passive 90-degree hip flexion (numeric rating scale)

Time frame: 1, 2, 5, 7 and 24 hours after completion of total hip replacement

Worst pain during ambulation on the day of surgery

Time frame: 5 hours after completion of total hip replacement

Time from completion of surgery to first dose of opioid

Time frame: 24 hours after completion of total hip replacement

Intensity of nausea on time of examination (numeric rating scale)

Time frame: 1, 2, 5, 7 and 24 hours after completion of total hip replacement

Incidences of emesis 0-18 hours after total hip replacement.

Time frame: 0-18 hours after completion of total hip replacement

Cumulated dose of ondansetron 0-18 hours after total hip replacement

Time frame: 0-18 hours after completion of total hip replacement

Data from ClinicalTrials.gov

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