Myocardial Fibrosis, Function and Aging

Hospices Civils de Lyon100 enrolled

Overview

In normal ageing, the impact of myocardial fibrosis on myocardial function is unclear as diastolic function is reported to change according to age. The objective is to explore the relationship between myocardial function changes, with local (T1 and diffusion) fibrosis measures with Magnetic Resonance Imaging (MRI) as well as global measures of fibrosis (skin auto-fluorescence and collagen blood-biomarkers).

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

100

Conditions

Healthy

Interventions

Blood samplingBIOLOGICAL

Blood sampling will be performed at inclusion to investigate some biological eligibility criteria, and the day of MRI in order to analyse fibrosis biomarkers and collagen synthesis biomarkers

MRIDEVICE

MRI will be performed to measure interstitial fibrosis

Skin auto-fluorescenceBIOLOGICAL

Skin auto-fluorescence measures will be performed to measure advanced glycation end-products (AGE) produced by collagen degradation

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * physical activity ≤ 3 x(30') per week * no history of smoking, diabetes, myocardial infarction, heart failure, hypertension (\<140 or \<90 mmHg) and no anti-hypertensive or cardiovascular-related medications * no familial history of early myocardial ischemia * body mass index (BMI) \<30kg/m2 * normal routine lipid blood analysis * glycemia \<1.26g/l * normal electrocardiogram (ECG) Exclusion Criteria: * arrhythmia * hepatic insufficiency * pregnancy * claustrophobia * MRI contrast allergy, * general contraindications to MRI such as pacemaker, etc.

Locations (1)

Département de Radiologie, CHU Saint-Etienne - Hôpital Nord

Saint-Etienne, France

RECRUITING

Outcomes

Primary Outcomes

Regional myocardial strain

Segmental measures of systolic and diastolic strains with magnetic resonance imaging (MRI)

Time frame: The day of MRI

Secondary Outcomes

MRI T1 value

This value is an indicator of interstitial fibrosis and extracellular volume

Time frame: The day of MRI, before gadolinium injection

MRI T1 value

Diminution of this value after gadolinium injection is an indicator of increasing quantity of interstitial fibrosis and extracellular volume

Time frame: The day of MRI, 15 minutes after gadolinium injection

Apparent Diffusion Coefficient (ADC) with MRI

ADC is measured with diffusion weighted imaging

Time frame: The day of MRI

Blood carboxy-terminal propeptide of procollagen type I (PICP) rate

Collagen blood biomarker analysis

Time frame: The day of MRI

Blood amino-terminal propeptide of procollagen type III (PIIINP) rate

Collagen blood biomarker analysis

Time frame: The day of MRI

Advanced Glycation End-products (AGE) rate

Skin auto-fluorescence AGE measures

Time frame: The day of MRI

Central Contacts

Pierre CROISILLE, MD, PhD

CONTACT

+33 477 127 584 croisille@creatis.insa-lyon.fr

Data from ClinicalTrials.gov

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