The purpose of this study is to evaluate the short- and long-term efficacy and safety of Acthar for the treatment of adults with non-infectious retinal vasculitis.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
40
H.P. Acthar Gel is an adrenocorticotropic hormone (ACTH) analogue indicated for ophthalmic diseases.
Ocular Immunology & Uveitis Foundation
Waltham, Massachusetts, United States
RECRUITINGPercentage of responders to Acthar at the end of treatment.
A responder will be defined by the binominal presence or absence of active retinal vasculitis as evaluated at Week 24. Active retinal vasculitis is defined as angiographic leakage from retinal arterioles, venules, or capillaries as determined by investigator, seen on wide-field angiography. Complete resolution or absence of active retinal vasculitis at Week 24 is considered success or "remission".
Time frame: 24 Weeks
Presence or absence of active retinal vasculitis at all other time points.
Time frame: 1 Day to 24 Weeks
Safety assessments, including drug tolerability and adverse events; other ocular and/or systemic complications.
Time frame: 1 Day to 24 Weeks
Percentage of patients requiring rescue therapy.
Time frame: 1 Day to 24 Weeks
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