The metabolic effect of oncometabolic surgery (long limb Roux-en Y reconstruction) for early gastric cancer patients has been revealed in a few pilot studies. However, the nutritional safety has not been dealt with in previous literatures. This is a prospective pilot study for evaluating the nutritional safety and metabolic benefits of oncometabolic surgery for obese early gastric cancer patients.
We performed long limb uncut Roux-en Y gastrojejunostomy (uRYGJ) in 20 patients with clinical T1N0 stage and preoperative body mass index (BMI) ≥ 32.5 kg/m2 or ≥ 27.5 kg/m2 with co-morbidities between September 2015 and July 2016. The primary endpoint was the incidence of micronutrients' deficiency (iron, folate, vitamin B12) at postoperative 1 year and secondary endpoints were anemia incidence, BMI change and remission rates of co-morbidities.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
20
The length of biliopancreatic limb is 50cm and the length of Roux limb is 100cm. (long limb uncut Roux-en-Y gastrojejunostomy) These limbs are longer than the conventional uncut Roux-en-Y reconstruction for gastric cancer patients.
micronutrients' deficiency (iron, folate, vitamin B12)
Iron deficiency : serum ferritin \< 20 μg/dL, Vitamin B12 deficiency : serum vitamin B12 \< 200 pg/mL,
Time frame: postoperative 1-year
anemia incidence
Iron deficiency anemia : anemia with concomitant iron deficiency, Anemia of chronic illness : anemia with serum ferritin \> 20 μg/dL, Anemia from vitamin B12 deficiency : megaloblastic anemia (MCV \>100 fL) with vitamin B12 deficiency
Time frame: postoperative 1-year
Body mass index (BMI) change
Preoperative BMI minus postoperative BMI
Time frame: postoperative 1-year
Remission rates of co-morbidities
Time frame: postoperative 1-year
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