Assessment of Lung Movement With Computed Tomography (CT)

University of Missouri-Columbia25 enrolled

Overview

The purpose of this study is to determine whether patient with ILD have altered lung compliance on chest CT before they have macroscopic structural changes on CT.

Interstitial lung disease (ILD) is a group of lung disorders in which the lung tissues become inflamed and then damaged. Idiopathic Pulmonary Fibrosis (IPF) is one of the subtypes of ILD which has characteristic histological and CT features. It is well known that microscopic fibrosis occurs in the lungs of IPF patients well before the structural changes of fibrosis become apparent on CT. By combining sophisticated image analysis with CT scans obtained at full inspiration and full expiration, it may be possible to detect earlier changes of IPF than currently possible by looking at macro structural features alone. With the recent development of new therapeutics for IPF, early detection of the disease and improved monitoring of treatment efficacy will become important. Using CT to assess regional lung compliance has the potential to become an easily translated clinical tool.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Interstitial Lung Disease

Interventions

Chest CTDEVICE

Inspiration and expiration chest CT

Pulmonary Function TestingDIAGNOSTIC_TEST

Measure lung function

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Subjects with ILD: Subjects must have a physician diagnosis of ILD and be in stable pulmonary condition at the time of the CT * Healthy subjects: Subjects must have no history of pulmonary disease and smoked less than 100 cigarettes in their lifetime Exclusion Criteria: * Subjects less than 18 years of age

Locations (1)

University of Missouri-Columbia

Columbia, Missouri, United States

Outcomes

Primary Outcomes

Lung Motion as Assessed by CT

A computer algorithm will compare the inspiration and expiration CT scans to determine regional lung motion.

Time frame: Study visit 1 of a single visit study

Secondary Outcomes

Lung Motion: Lobar Strain Which is a Ratio

Lobar strain (S): the volumetric strain of each lobe i \[i = Right Upper (RU), Right Lower (RL), Left Lower (LL), and Left Upper (LU)\] as the difference in lobe volume between the expanded and contracted states, normalized by the lobe volume in the expanded state

Time frame: Study visit 1 of a single visit study

Data from ClinicalTrials.gov

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