The Interactive Physical and Cognitive Exercise System

Union College, New York31 enrolled

Overview

This study is intended to clarify the benefits to brain health and thinking processes that result from different forms of exercise. In particular, this study will investigate the possible benefits of physical exercise (such as pedaling an under-table stationary elliptical) or mental exercise (such as playing a videogame on a portable tablet), or combining these activities together (as in the iPACES™ exergame).

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Alzheimer Disease, Early Onset MCI Aging Mild Cognitive Impairment Neurocognitive Disorder

Interventions

physical exercise alone (PES) firstBEHAVIORAL

following 2-week placebo for all participants, participants in this arm will then start their active intervention with a randomly assigned 2-week physical exercise-only intervention, then 2-week cognitive exercise-only intervention, then 2-week and 3 month intervals of iPACES™ (interactive physical and cognitive exercise)

cognitive exercise alone (iCE) firstDEVICE

following 2-week placebo for all participants, participants in this arm will then start their active intervention with a randomly assigned 2-week cognitive exercise-only intervention, then 2-week physical exercise-only intervention, then 2-week and 3 month intervals of iPACES™ (interactive physical and cognitive exercise)

interactive Physical and Cognitive Exercise (iPACES™)DEVICE

Eligibility

Sex: ALLMin age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * co-residing older adults (e.g., spouses, partners, roommates, relatives) * both at least 50 years of age * normative/typical cognitive function or those with Mild Cognitive Impairment (MCI) or mild Neurocognitive Disorder (mNCD) or early Alzheimer's disease * adequate vision and dexterity for on-screen assessments * able to pedal an under-table elliptical * permission of primary care provider and cardiologist (if applicable) Exclusion Criteria: * history of seizure * Parkinson's disease * significant dementia/memory loss

Outcomes

Primary Outcomes

executive function composite score

comprised of scores from Stroop, Trails, and Flanker

Time frame: change over time from baseline to 3 months

Secondary Outcomes

brain-derived neurotrophic factor (BDNF)

change in amount in saliva sample over time (pg/ml) per ELISA

Time frame: change over time from baseline to 3 months

Sit-Stand Test

scored performance on time and technique to move from sitting on floor to standing

Time frame: change over time in score from baseline to 3 months