Sit-to-stand Test in Cystic Fibrosis Children and Adolescents

Groupe Hospitalier du Havre36 enrolled

Overview

Cystic fibrosis (CF) is a chronic hereditary respiratory disease. Exercise testing is part of CF patients regular assessment. Cardio-Pulmonary Exercise Testing (CPET) is currently considered as the gold standard to assess physical capacities. However, simple field tests are emerging. These tests are easier to perform especially in a population of CF children and adolescents. The 1minute Sit-To-Stand test have recently been evaluated in CF adults. This test correlates with maximal oxygen consumption during CPET. The investigators hypothesized that this test also correlates with 6-Minute Walking distance (during a 6-min Walk Test), quadriceps strength, respiratory muscles strength and health-related quality of life.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SCREENING

Masking

NONE

Enrollment

Conditions

Cystic Fibrosis

Interventions

Eligibility

Sex: ALLMin age: 6 YearsMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Cystic Fibrosis * Exacerbation-free last month before inclusion Exclusion Criteria: * Cardiovascular, neurological or musculoskeletal contra-indications to exercise testing * Other respiratory disease (kyphoscoliosis, asthma ...) * Exacerbation * Unability to carry out field tests

Locations (3)

Hôpital Côte de Nacre

Caen, France

Le Havre Hospital

Le Havre, France

CHU de Rouen

Rouen, France

Outcomes

Primary Outcomes

Correlation between number of repetitions (STS Test) and 6-Minute Walking Distance

Comparison between the results of these two submaximal exercise tests

Time frame: This outcome will be measured after both tests realization up to 15 minutes.

Secondary Outcomes

Correlation between number of repetitions (STS test) and Maximal Inspiratory Pressure (MIP)

MIP will be assessed using a microRPM Puma manometer.

Time frame: MIP will be measured after inclusion in the hour before field tests realization.

Correlation between number of repetitions (STS test) and Maximal Expiratory Pressure (MEP)

MEP will be assessed using a MicroRPM Puma manometer.

Time frame: MEP will be measured after inclusion in the hour before field tests realization.

Correlation between number of repetitions (STS Test) and health-related quality of life

HRQoL will be measured by the Cystic Fibrosis Questionnaire

Time frame: HRQoL testing will be carried out after inclusion in the hour before field tests realization.

Correlation between number of repetitions (STS Test) and quadriceps strength.

Quadriceps strength will be assessed by handheld dynamometry using a MicroFet II dynamometer.

Time frame: Quadriceps strength will be assessed after inclusion in the hour before field tests realization.

Correlation between number of repetitions (STS Test) and forced vital capacity (FVC)

FVC will be assessed with non invasive spirometry.

Time frame: Spirometric test will be carried out before field tests realization.

Correlation between number of repetitions (STS Test) and forced expiratory volume in 1 second (FEV1)

FEV1 will be assessed with non invasive spirometry.

Time frame: Spirometric test will be carried out in the last 3 months before field tests realization.

Correlation between number of repetitions (STS Test) and number of exacerbations / year.

Time frame: Number of exacerbations / year will assess the number of exacerbations in the last year before inclusion and will be assessed during the initial survey in the hour before field test realization.

Differences in dyspnea and muscular fatigue.

These outcomes will be assessed using Modified Borg Scale (0-10 points)

Time frame: These outcomes will be assessed during both field tests. These tests will be separate by a 30 minutes rest period. Date will be collected at the end of each test up to 15 minutes.

Differences in Heart Rate.

These outcomes will be assessed using pulse oximetry.

Time frame: These outcomes will be assessed during both field tests. These tests will be separate by a 30 minutes rest period. Date will be collected at the end of each test up to 15 minutes.

Differences in Respiratory Rate.

These outcomes will be assessed using pulse oximetry.

Time frame: These outcomes will be assessed during both field tests. These tests will be separate by a 30 minutes rest period. Date will be collected at the end of each test up to 15 minutes

Differences in Oxygen Saturation.

These outcomes will be assessed using pulse oximetry.

Time frame: These outcomes will be assessed during both field tests. These tests will be separate by a 30 minutes rest period. Date will be collected at the end of each test up to 15 minutes.